The Old Residency Museum is housed in a colonial building, designed in Scotland and shipped to Nigeria during the 1880s. It previously housed the British colonial administration in Nigeria. The museum holds the largest collection of Nigerian documents and artefacts in the world. It focusses on the history of the Calabar and Cross River Regions, as well as slavery, and is managed by the National Commission for Museums.

The first exhibition encountered by visitors on their entry to the museum explores the four centuries of the trade in people that permeated Nigeria and the region. There is a significant display of European items that were used as trade goods in exchange for enslaved Africans. This includes Venetian glass beads, pewter pots, ceramic pots, shaving sets and guns. Other displays include items that illustrate the brutal nature of enslavement, including chains and manacles.

The museum's other exhibition examines the production processes of palm oil, as one of the most important exports to Calabar, after the abolition of the slave trade.