The National Civil Rights Museum is housed in the Lorraine Motel, where civil rights leader Dr. Martin Luther King Jr. was assassinated on 4 April, 1968. It was founded in 1991 with the mission of sharing and raising awareness about the lessons and legacies from the Civil Rights Movement. The museum makes use of historic collections and a range of interactive exhibits, including film and audio, to tell these stories. Recently renovated in 2013-14, the museum is one of the top rated by the American Alliance of Museums and was a founding member of the International Coalition of Sites of Conscience.

The museum has five permanent exhibitions that include 260 artefacts, 40 film installations, oral histories and interactive media to guide visitors through five centuries of history. The exhibitions explore Civil Rights protest techniques- including sit ins, bus boycotts and freedom rides- as well as the Black Power movement and the assasination of Martin Luther King Jr. and its aftermath on the Civil Rights movement.

The first exhibition that visitors enter explores the longer 'Culture of Resistance' that was present in the United States prior to the Civil Rights movement, as seen through resistance to the system of slavery that dominated the country for centuries. Focussing on the period 1619-1869, the exhibition includes large scale interactive maps that emphasise the global impact of the transatlantic slave trade. There are films and art installations in the form of sculptures that show the terrible conditions inflicted on the enslaved people. Illuminated channels provide statistics and further information, including the number of people captured, goods cultivated and wealth created.

The museum also has facilities for temporary exhibitions, both on the site and online, and runs an immersive education programme for both children and adults.