There are an estimated 57,700 people in modern slavery in the US according to GSI estimates. The US attracts migrants and refugees who are particularly at risk of vulnerability to human trafficking. Trafficking victims often responding to fraudulent offers of employment in the US migrate willingly and are subsequently subjected to conditions of involuntary servitude in industries such as forced labour and commercial sexual exploitation. Low, semi- and unskilled domestic and foreign labourers are at risk of forced labour within the agricultural sector. Migrants from Mexico have been found in conditions of forced labour in the USA, where they are subjected to poor living and working conditions including excessive working hours, withholding and non-payment of salaries, confinement to plantations, refusal of medical care and physical and sexual abuse. Ana crossed the Mexico-US border seeking the American Dream and to provide a better life for her son. However instead, she found herself forced to work long hours picking fruit, with little pay and poor living conditions under the threat of violence. Ana was finally freed when two people she had asked for help called the police.

The United States is a source, transit, and destination country for men, women, transgender individuals, and children—both U.S. citizens and foreign nationals—subjected to sex trafficking and forced labour. Trafficking occurs in both legal and illicit industries, including in commercial sex, hospitality, traveling sales crews, agriculture, seafood, manufacturing, janitorial services, construction, restaurants, health care, care for persons with disabilities, salon services, fairs and carnivals, peddling and begging, drug smuggling and distribution, and child care and domestic work.  This individual was sold into to slavery from Mexico to the US by her sister at the age of 13. Denied access to her baby, she was forced to provide sexual services for both men and women. Though she was promised her baby would be taken care of, neither she nor the baby were provided medical care and the baby died of leukaemia. This individual was finally able to escape out of a window and go to the police, however, after being deported to Tijuana returned to the US where her trafficker told her he was finally in love with her.