The Sendinggestig opened in 1977, situated in an old mission church which still functions for ceremonial purposes though lost its congregation – which mainly comprised poorer black and coloured people – when the terms of the Group Areas Act were applied to inner city spaces. The museum is colloquially referred to as the ‘Slave Church’, reflecting the presence of enslaved people in its original congregation founded in 1804. It is one of 28 museums affiliated with the Western Cape Provincial Government’s Museum Service. As well as providing funding, the Museum Service offers technical support in developing exhibitions. The Sendinggestig was originally conceived as a mission museum, and updated displays installed by the Museum Service in 2011 reflect this focus.

The displays installed in 2011 move beyond Eurocentric interpretations of history to offer a more inclusive history of mission activity and religious freedoms in the Cape Town area. Reference, for example, is made to the connections between slavery and the development of Islam in South Africa. In offering the building space to outside groups and performers, the museum also works to provide opportunities for alternative interpretation. This includes groups who identify with enslaved and Khoisan people as ancestors, and seek to reimagine their lives through song, poetry, and dance. A regular series of public events are held and attract sizeable audiences, whilst 1 December Emancipation Day is marked annually.

The Congo Atrocity Lantern Lecture was devised by the British missionary couple Reverend John Harris and his wife Alice Seeeley Harris. Based on their time spent in the Congo Free state, it combined her atrocity photography with witness statements from a variety of sources. The lecture toured Britain and proved so popular that a standard set of lecture notes was developed so that the talk could be delivered by different speakers. The lecture icluded material designed to promote awareness of the brutal slave labour regime that occurred under King Leopold II. It also included material promoting British missionary activities in the area. The language and the accompanying slides were part of a discourse on the European 'civilising mission' and were used to justify the expansion of the colonial project as well as antislavery sentiment.