The museum is housed within Ussher Fort, one of three European forts built in the Accra region of Ghana during the mid-seventeenth century. Developed by Ghana's Ministry of Tourism, with support and funding from UNESCO, the museum opened in 2007.

The museum aims to highlight the history of the transatlantic slave trade in Ghana. Beginning with the development of the trade in human beings, the museum covers the history through to British abolition.

The collection is varied and includes items once used by both captors and victims. There are weapons, African household items and a model of a slave vessel. The museum also contains paintings of several key abolition figures, including William Wilberforce and Harriet Tubman.